Sunday, 16 December, 2018

Study to examine possible effects of cannabis compound for common movement disorder

Pot Stocks Gain After Tilray Gets U.S. Approval to Import Medical Cannabis Tilray approved to export medical cannabis formulation to U.S. for clinical trial
Delores Daniels | 21 September, 2018, 07:15

Tilray will be exporting to the University of California San Diego capsules with two active ingredients - cannabidiol and tetrahydrocannabinol, better known as CBD and THC - extracted from the cannabis plant for a clinical trial as a potential treatment for essential tremor, a neurological disorder that causes uncontrollable shaking. Unlike Parkinson's disease, which causes shaking when someone is not moving, people with essential tremors shake when they are, making everyday activities like writing, drinking and speaking hard.

"This work expands CMCR's commitment to develop an evidence-based approach in the area of cannabinoid therapeutics", said Dr. Igor Grant, director of the Center for Medicinal Cannabis Research. The capsule cannabinoid formulation for this study will be provided by Tilray, a Canada-based cannabis company specializing in the research, cultivation, production and global distribution of cannabis and cannabinoids.

Currently, ET is treated with drugs originally developed to treat high blood pressure, seizures, and even Botox.

The study is expected to begin in early 2019, with the principle investigator being Dr. Fatta Nahab, a board-certified neurologist and director of the Functional Imaging of Neurodegenerative Disorders Lab at the UC San Diego health's movement disorder centre.

"Essential tremor is ten times more common than Parkinson's and yet nobody really knows about essential tremor", Nahab said.

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It will be used to examine its safety, tolerability and effectiveness for treatment of Essential Tremor (ET) in adults.

While several states have legalized cannabis for medical or recreational use, marijuana remains illegal under US federal law.

"Tilray is proud to support this crucial research", Catherine Jacobson, Tilray's director of clinical research, said in a press release.

With its shares climbing, Tilray also recently came under fire from short seller Citron Research, which warned that the cannabis-related IPO pipeline "will detract capital from Tilray and traders will have new toys to play with".

The research will include 16 adult participants who have been diagnosed with ET.

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The clinical trial supports TLRY's medical cannabis prospects in the USA and globally as it competes with (Canopy Growth) in an IP-arms race.

"The company also has boots on the ground in eight countries including Australia and New Zealand and was the first Canadian LP to ship cannabis products into Germany's medical cannabis market", noted Canaccord Genuity last week. "We have been able to prove to the FDA that we can manufacture investigational study drugs containing cannabinoids that meet their standards".

Cannabis is a Schedule 1 drug, as defined by the Drug Enforcement Administration (DEA), and availability for research purposes is strictly limited. "There are definitely situations where, when there's no source in the USA, a registrant can import a cannabis-derived drug from another country".

NIDA, which does intend to expand how much marijuana the University of MS grows for research, does not yet provide marijuana compounds in capsules, said Don Stanford, assistant director of the Research Institute of Pharmaceutical Sciences at the university.

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